Ergebnisse
| 23. Januar 2022 | ||
| Jahn Regensburg | 1 – 2 | Holstein Kiel |
| Hannover 96 | 0 – 0 | Dynamo Dresden |
| 22. Januar 2022 | ||
| Erzgebirge Aue | 0 – 5 | Schalke 04 |
| Ingolstadt 04 | 0 – 2 | Darmstadt |
| Hansa Rostock | 0 – 0 | Heidenheim |
| Paderborn | 3 – 4 | Werder Bremen |
| 21. Januar 2022 | ||
| Fortuna Düsseldorf | 0 – 1 | Nürnberg |
| Hamburg | 2 – 1 | FC St. Pauli |
| 16. Januar 2022 | ||
| Schalke 04 | 1 – 1 | Holstein Kiel |
| Heidenheim | 2 – 1 | Ingolstadt 04 |
| Sandhausen | 0 – 3 | Jahn Regensburg |
| 15. Januar 2022 | ||
| Darmstadt | 2 – 2 | Karlsruhe |
| Nürnberg | 1 – 2 | Paderborn |
| FC St. Pauli | 2 – 2 | Erzgebirge Aue |
| Werder Bremen | 3 – 0 | Fortuna Düsseldorf |
| 14. Januar 2022 | ||
| Hansa Rostock | 0 – 1 | Hannover 96 |
| Dynamo Dresden | 1 – 1 | Hamburg |
| 19. Dezember 2021 | ||
| Karlsruhe | 2 – 2 | Hansa Rostock |
| Jahn Regensburg | 0 – 2 | Darmstadt |
| Hannover 96 | 1 – 4 | Werder Bremen |
Tabelle: 2 Bundesliga
| # | Mannschaft | Spiele | S | U | N | T | GT | TD | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Darmstadt | 20 | 12 | 3 | 5 | 45 | 22 | +23 | 39 |
| 2 | FC St. Pauli | 20 | 11 | 4 | 5 | 40 | 27 | +13 | 37 |
| 3 | Werder Bremen | 20 | 10 | 5 | 5 | 39 | 28 | +11 | 35 |
| 4 | Schalke 04 | 20 | 10 | 4 | 6 | 40 | 24 | +16 | 34 |
| 5 | Hamburg | 20 | 8 | 10 | 2 | 34 | 20 | +14 | 34 |
| 6 | Heidenheim | 20 | 10 | 4 | 6 | 25 | 25 | +0 | 34 |
| 7 | Nürnberg | 20 | 9 | 6 | 5 | 29 | 23 | +6 | 33 |
| 8 | Jahn Regensburg | 20 | 9 | 4 | 7 | 39 | 30 | +9 | 31 |
| 9 | Paderborn | 20 | 8 | 6 | 6 | 36 | 26 | +10 | 30 |
| 10 | Karlsruhe | 19 | 6 | 8 | 5 | 33 | 30 | +3 | 26 |
| 11 | Holstein Kiel | 20 | 6 | 7 | 7 | 26 | 32 | -6 | 25 |
| 12 | Dynamo Dresden | 20 | 7 | 3 | 10 | 21 | 26 | -5 | 24 |
| 13 | Hannover 96 | 20 | 6 | 6 | 8 | 15 | 27 | -12 | 24 |
| 14 | Hansa Rostock | 20 | 5 | 6 | 9 | 21 | 32 | -11 | 21 |
| 15 | Fortuna Düsseldorf | 20 | 5 | 5 | 10 | 23 | 29 | -6 | 20 |
| 16 | Sandhausen | 19 | 4 | 5 | 10 | 20 | 39 | -19 | 17 |
| 17 | Erzgebirge Aue | 20 | 3 | 6 | 11 | 17 | 37 | -20 | 15 |
| 18 | Ingolstadt 04 | 20 | 2 | 4 | 14 | 15 | 41 | -26 | 10 |